IQV (NYSE:IQV) Q4 Revenue Surpasses Estimates, 10.3% YoY; Full-Year EPS Guidance Misses

IQVIA (NYSE:IQV) reported Q4 CY2025 revenue of $4.36 billion, up 10.3% year-on-year and exceeding Wall Street estimates by $2.9 billion. Non-GAAP profit of $3.42 per share was slightly above consensus, and the midpoint of its $17.25 billion full-year guidance was 1% above estimates. Excluding currency, constant currency sales grew 4.1% YoY. Over the past five years, IQVIA posted 7.5% annualized revenue growth and 13.1% CAGR in EPS, outpacing the S&P 500 and driven by operational leverage and a 12% share count reduction. This quarter’s operating margin of 14.4% declined slightly from last year, while the five-year operating margin expanded 3.3 percentage points to 12.7%. Looking ahead, sell-side analysts project 4.7% revenue growth and 7.9% EPS expansion over the next 12 months, with the stock trading at $201.50 as of February 5, 2026.