OpenEvidence Raises $250M at $12B Valuation, Doubles Value in Three Months

OpenEvidence, a U.S.-based AI startup providing clinical decision support tools to physicians, raised $250 million in a Series D round at a $12 billion valuation on January 21, 2026, doubling its value from $6 billion in October 2025. The funding was co-led by Thrive Capital and DST Global, bringing total capital raised to nearly $700 million. The company’s AI-powered medical search engine is used daily by over 40% of U.S. physicians across more than 10,000 hospitals and medical centers. It processes approximately 18 million clinical consultations monthly—up from 3 million in early 2025—by synthesizing data from peer-reviewed journals and guidelines. Partnerships with the New England Journal of Medicine and the American Medical Association help ensure accuracy and trust. OpenEvidence plans to use the new funds to expand R&D and scale its AI infrastructure.